Iridocorneal endothelial syndrome
- ICE syndrome
- Visible changes in the iris (the colored part of the eye that regulates the amount of light entering the eye)
- Swelling of the cornea, and
- The development of glaucoma (a disease that can cause severe vision loss when normal fluid inside the eye cannot drain properly)
ICE syndrome, is more common in women than men, most commonly diagnosed in middle age, and is usually present in only one eye. The condition is actually a grouping of three closely linked conditions: Cogan-Reese syndrome; Chandler's syndrome; and essential (progressive) iris atrophy. The cause of ICE syndrome is unknown, however there is a theory that it is triggered by a virus that leads to swelling of the cornea. While there is no way to stop the progression of the condition, treatment of the symptoms may include medication for glaucoma and corneal transplant for corneal swelling.
- Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). May 2013; https://www.nei.nih.gov/health/cornealdisease/. Accessed 12/31/2014.
- Gregory W.Oldham, MD and Sarwat Salim MD, FACS. Iridocorneal Endothelial Syndrome and Secondary Glaucoma. EyeWiki: May 7, 2015; http://eyewiki.aao.org/Iridocorneal_Endothelial_Syndrome_and_Secondary_Glaucoma. Accessed 12/1/2015.
- The National Eye Institute (NEI) was established by Congress in 1968 to protect and prolong the vision of the American people. Click on the link to view information on this topic.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Iridocorneal endothelial syndrome. Click on the link to view a sample search on this topic.