Unicentric Castleman disease
Other Names for this Disease
- Localized Castleman disease
- Unicentric angiofollicular ganglionic hyperplasia
- Unicentric angiofollicular lymph hyperplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
On this page
The exact underlying cause of unicentric Castleman disease (UCD) is poorly understood. However, some scientists suspect that an increased production of interleukin-6 (IL-6) by the immune system may contribute to the development of UCD. IL-6 is a substance normally produced by cells within the lymph nodes that helps coordinate the immune response to infection. Increased production of IL-6 may result in an overgrowth of lymphatic cells, leading to many of the signs and symptoms of UCD.
Last updated: 6/24/2015
- Castleman's Disease. NORD. December 8, 2010; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/532/viewAbstract. Accessed 10/1/2013.
- Jennifer R Brown, MD, PhD; Jon C Aster, MD; Nikhil C Munshi, MD. Unicentric Castleman's disease. UpToDate. November 2013; Accessed 6/24/2015.