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Genetic and Rare Diseases Information Center (GARD)

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Unicentric Castleman disease


Other Names for this Disease
  • Localized Castleman disease
  • Unicentric angiofollicular ganglionic hyperplasia
  • Unicentric angiofollicular lymph hyperplasia
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Overview

Unicentric Castleman disease (UCD) is a rare condition that affects the lymph nodes and related tissues. It is a form of Castleman disease that is "localized" to a single set of lymph nodes (as opposed to multicentric Castleman disease which has more widespread effects). UCD often starts as an enlarged lymph node. Depending on the location of this enlarged node, some people will have no additional features of the condition, while others will develop symptoms when it pushes on nearby organs and/or tissues. The exact underlying cause of UCD is currently unknown. Treatment typically includes surgical removal of the affected lymph node.[1][2][3]
Last updated: 6/24/2015

References

  1. Castleman Disease. American Cancer Society. July 2014; http://www.cancer.org/cancer/castlemandisease/detailedguide/index.
  2. Jennifer R Brown, MD, PhD; Jon C Aster, MD; Nikhil C Munshi, MD. Unicentric Castleman's disease. UpToDate. November 2013; Accessed 6/24/2015.
  3. Neetu Radhakrishnan, MD. Castleman Disease. Medscape Reference. January 2015; http://emedicine.medscape.com/article/2219018-overview.
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Basic Information

  • The American Cancer Society provides detailed information about Unicentric Castleman disease. Click on the link to access this information. 
  • MayoClinic.com provides an information page for this topic. Click on the link to view this information.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
    Castleman disease
    Localized Castleman disease
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Unicentric Castleman disease. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Localized Castleman disease
  • Unicentric angiofollicular ganglionic hyperplasia
  • Unicentric angiofollicular lymph hyperplasia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.