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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Unicentric Castleman disease


Other Names for this Disease
  • Localized Castleman disease
  • Unicentric angiofollicular ganglionic hyperplasia
  • Unicentric angiofollicular lymph hyperplasia
Related Diseases
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Cause

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What causes unicentric Castleman disease?

The exact underlying cause of unicentric Castleman disease (UCD) is poorly understood. However, some scientists suspect that an increased production of interleukin-6 (IL-6) by the immune system may contribute to the development of UCD. IL-6 is a substance normally produced by cells within the lymph nodes that helps coordinate the immune response to infection. Increased production of IL-6 may result in an overgrowth of lymphatic cells, leading to many of the signs and symptoms of UCD.[1][2]

Last updated: 6/24/2015

References
  1. Castleman's Disease. NORD. December 8, 2010; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/532/viewAbstract. Accessed 10/1/2013.
  2. Jennifer R Brown, MD, PhD; Jon C Aster, MD; Nikhil C Munshi, MD. Unicentric Castleman's disease. UpToDate. November 2013; Accessed 6/24/2015.


Other Names for this Disease
  • Localized Castleman disease
  • Unicentric angiofollicular ganglionic hyperplasia
  • Unicentric angiofollicular lymph hyperplasia
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.