Bilateral perisylvian polymicrogyria
- Congenital bilateral perisylvian syndrome
- Perisylvian syndrome
- Perisylvian syndrome, congenital bilateral
Your QuestionIf a child is the only one affected with perisylvian syndrome in his family, can the inheritance of the syndrome be determined? Would perisylvian syndrome in a male child come from the mother or the father, or both? Is genetic testing for this syndrome available?
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Questions on this page
- What causes bilateral perisylvian polymicrogyria?
- Is bilateral perisylvian polymicrogyria inherited?
- If a child is the only one affected with bilateral perisylvian polymicrogyria in his family, can the inheritance pattern of the syndrome be determined? Would this condition in a male child come from the mother or the father, or both?
- Is genetic testing available for bilateral perisylvian polymicrogyria?
Specific non-genetic causes of polymicrogyria have been recognized, including exposure to cytomegalovirus infection (CMV) during pregnancy. Polymicrogyria has also been associated with certain complications in twin pregnancies.
Rarely, more than one family member may be affected by BPP. These cases may follow an autosomal dominant, autosomal recessive, or X-linked pattern of inheritance.
If a child is the only one affected with bilateral perisylvian polymicrogyria in his family, can the inheritance pattern of the syndrome be determined? Would this condition in a male child come from the mother or the father, or both?
If you or a family member has been diagnosed with this condition, you may find it helpful to speak with a genetics professional. To find a genetics clinic, we recommend that you contact your primary healthcare provider for a referral. The following online resources can also help you find a genetics professional in your community:
- The National Society of Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.
- Congenital Bilateral Perisylvian Syndrome. NORD. 2015; http://rarediseases.org/rare-diseases/congenital-bilateral-perisylvian-syndrome/.
- POLYMICROGYRIA, BILATERAL PERISYLVIAN, X-LINKED. OMIM. April 2014; http://www.omim.org/entry/300388.
- Chang B, Walsh CA, Apse K & Bodell A. Polymicrogyria Overview. Gene Reviews. August 6, 2007; http://www.ncbi.nlm.nih.gov/books/NBK1329/. Accessed 3/9/2015.