Other Names for this Disease
- Chandler syndrome
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While it is not possible to halt the progression of Chandler's syndrome, the glaucoma associated with this disease can be treated with medications and/or filtering surgery. Eye drops used in managing glaucoma decrease pressure in the eye by helping the eye's fluid drain more efficiently and/or decreasing the amount of fluid made by the eye. Drugs used to treat glaucoma are classified according to their active ingredient. These include prostaglandin analogs, beta blockers, alpha agonists, and carbonic anhydrase inhibitors. Combination drugs may be necessary for some patients. If these medications do not successfully treat the glaucoma, surgery may be indicated. Trabeculectomy may be used to treat glaucoma. In some cases, multiple procedures may be necessary. The corneal swelling associated with Chandler's syndrome may be treated through a cornea transplant. Further investigation is needed to determine the best way to manage this condition.
Last updated: 12/31/2014
- Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). May 2013; https://www.nei.nih.gov/health/cornealdisease/. Accessed 12/31/2014.
- What is Irido Corneal Endothelial Syndrome (ICE)?. Glaucoma Research Foundation. August 23, 2012; http://www.glaucoma.org/q-a/what-is-irido-corneal-endothelial-syndrome-ice.php. Accessed 12/31/2014.
- Denis P. Iridocorneal endothelial syndrome and glaucoma.. J Fr Ophtalmol. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17318107. Accessed 12/31/2014.
- Medication Guide. Glaucoma Research Foundation. October 10, 2014; http://www.glaucoma.org/treatment/medication-guide.php. Accessed 12/31/2014.
- Shields B, Sears ML. Chandler's Syndrome. National Organization for Rare Disorders (NORD). 2013; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/949/viewAbstract. Accessed 12/31/2014.
- Doe EA, Budenz DL, Gedde SJ, et al.. Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome.. Ophthalmology. 2001; http://www.ncbi.nlm.nih.gov/pubmed/11581050. Accessed 12/31/2014.
- Morris RW, Dunbar MT. Atypical presentation and review of the ICE syndrome.. Optometry. 2004; http://www.ncbi.nlm.nih.gov/pubmed/14717277. Accessed 12/31/2014.
- Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.
- ClinicalTrials.gov lists trials that are studying or have studied Chandler's syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.