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Diseases

Genetic and Rare Diseases Information Center (GARD)

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Chandler's syndrome


Other Names for this Disease
  • Chandler syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might Chandler's syndrome be treated?

While it is not possible to halt the progression of Chandler's syndrome, the glaucoma associated with this disease can be treated with medications and/or filtering surgery.[1][2][3] Eye drops used in managing glaucoma decrease pressure in the eye by helping the eye's fluid drain more efficiently and/or decreasing the amount of fluid made by the eye.[4] Drugs used to treat glaucoma are classified according to their active ingredient. These include prostaglandin analogs, beta blockers, alpha agonists, and carbonic anhydrase inhibitors.[5][4] Combination drugs may be necessary for some patients.[4] If these medications do not successfully treat the glaucoma, surgery may be indicated.[5][4] Trabeculectomy may be used to treat glaucoma.[5][6] In some cases, multiple procedures may be necessary.[6] The corneal swelling associated with Chandler's syndrome may be treated through a cornea transplant.[5][1] Further investigation is needed to determine the best way to manage this condition.[7]
Last updated: 12/31/2014

References
  1. Facts About The Cornea and Corneal Disease. National Eye Institute (NEI). May 2013; https://www.nei.nih.gov/health/cornealdisease/. Accessed 12/31/2014.
  2. What is Irido Corneal Endothelial Syndrome (ICE)?. Glaucoma Research Foundation. August 23, 2012; http://www.glaucoma.org/q-a/what-is-irido-corneal-endothelial-syndrome-ice.php. Accessed 12/31/2014.
  3. Denis P. Iridocorneal endothelial syndrome and glaucoma.. J Fr Ophtalmol. 2007; http://www.ncbi.nlm.nih.gov/pubmed/17318107. Accessed 12/31/2014.
  4. Medication Guide. Glaucoma Research Foundation. October 10, 2014; http://www.glaucoma.org/treatment/medication-guide.php. Accessed 12/31/2014.
  5. Shields B, Sears ML. Chandler's Syndrome. National Organization for Rare Disorders (NORD). 2013; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/949/viewAbstract. Accessed 12/31/2014.
  6. Doe EA, Budenz DL, Gedde SJ, et al.. Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome.. Ophthalmology. 2001; http://www.ncbi.nlm.nih.gov/pubmed/11581050. Accessed 12/31/2014.
  7. Morris RW, Dunbar MT. Atypical presentation and review of the ICE syndrome.. Optometry. 2004; http://www.ncbi.nlm.nih.gov/pubmed/14717277. Accessed 12/31/2014.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Chandler's syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Chandler syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.