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Genetic and Rare Diseases Information Center (GARD)

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Chronic granulomatous disease


Other Names for this Disease
  • CGD
  • Chronic septic granulomatosis
  • Granulomatous disease, chronic
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Chronic granulomatous disease (CGD) is a rare, inherited immunodeficiency that affects certain white blood cells. People affected by this condition have immune systems that do not function properly, leaving the body vulnerable to chronic inflammation and frequent bacterial and fungal infections. The features of this condition usually develop in infancy or early childhood; however, milder forms may be diagnosed in the teen years or even in adulthood.[1][2] It is caused by changes (mutations) in any one of five different genes and is usually inherited in an autosomal recessive or X-linked recessive manner.[3] Treatment consists of continuous therapy with antibiotic and antifungal medications to treat and prevent infections.[1][4]
Last updated: 2/11/2015

References

  1. Roman Janusz Nowicki, MD, PhD. Chronic Granulomatous Disease. Medscape Reference. March 2013; http://emedicine.medscape.com/article/1116022-overview.
  2. Chronic Granulomatous Disease. NORD. September 2012; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/682/viewAbstract.
  3. Chronic Granulomatous Disease. Genetics Home Reference. August 2012; http://ghr.nlm.nih.gov/condition/chronic-granulomatous-disease.
  4. Sergio D Rosenzweig, MD; Steven M Holland, MD. Chronic granulomatous disease: Treatment and prognosis. UpToDate. November 2014; Accessed 2/11/2015.
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Basic Information

  • The CGD Society has an information page on Chronic granulomatous disease. Please click the link to access this resource.
  • Genetics Home Reference (GHR) contains information on Chronic granulomatous disease. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Institute of Allergy and Infectious Diseases (NIAID) supports scientists developing better ways to diagnose, treat, and prevent the many infectious, immunologic, and allergic diseases that afflict people worldwide. Click on the link to view information on this topic. 
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

Other Names for this Disease
  • CGD
  • Chronic septic granulomatosis
  • Granulomatous disease, chronic
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.