Chronic granulomatous disease
Other Names for this Disease
- Granulomatous disease, chronic
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immunodeficiency that affects certain white blood cells. People affected by this condition have immune systems that do not function properly, leaving the body vulnerable to chronic inflammation and frequent bacterial and fungal infections. The features of this condition usually develop in infancy or early childhood; however, milder forms may be diagnosed in the teen years or even in adulthood. It is caused by changes (mutations) in any one of five different genes and is usually inherited in an autosomal recessive or X-linked recessive manner. Treatment consists of continuous therapy with antibiotic and antifungal medications to treat and prevent infections.Chronic granulomatous disease (CGD) is a rare, inherited
Last updated: 2/11/2015
- Roman Janusz Nowicki, MD, PhD. Chronic Granulomatous Disease. Medscape Reference. March 2013; http://emedicine.medscape.com/article/1116022-overview.
- Chronic Granulomatous Disease. NORD. September 2012; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/682/viewAbstract.
- Chronic Granulomatous Disease. Genetics Home Reference. August 2012; http://ghr.nlm.nih.gov/condition/chronic-granulomatous-disease.
- Sergio D Rosenzweig, MD; Steven M Holland, MD. Chronic granulomatous disease: Treatment and prognosis. UpToDate. November 2014; Accessed 2/11/2015.
- The CGD Society has an information page on Chronic granulomatous disease. Please click the link to access this resource.
- Genetics Home Reference (GHR) contains information on Chronic granulomatous disease. This website is maintained by the National Library of Medicine.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Merck Manual for health care professionals provides information on Chronic granulomatous disease.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
CGD, autosomal recessive, cytochrome b-positive, type I
CGD, autosomal recessive, cytochrome b-positive, type II
CGD, autosomal recessive, cytochrome b-positive, type III
CGD, autosomal recessive, cytochrome b-negative
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Chronic granulomatous disease. Click on the link to view a sample search on this topic.