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Diseases

Genetic and Rare Diseases Information Center (GARD)

Chronic recurrent multifocal osteomyelitis


Other Names for this Disease
  • CRMO
  • Multifocal osteomyelitis, chronic
  • Chronic multifocal osteomyelitis
  • CMO
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Overview

Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone condition. Signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. Symptoms typically begin in childhood. CRMO may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, Majeed syndrome or DIRA. For most children, CRMO resolves after many years without lasting effects. However, CRMO can cause slow growth and permanent bone deformity.[1][2]
Last updated: 5/15/2013

References

  1. Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep. 2012 Apr;14(2):130-41; http://www.ncbi.nlm.nih.gov/pubmed/?term=22359228. Accessed 5/15/2013.
  2. Majeed syndrome. Genetics Home Reference. August 2009; http://www.ghr.nlm.nih.gov/condition/majeed-syndrome. Accessed 5/15/2013.
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In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Chronic recurrent multifocal osteomyelitis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • CRMO
  • Multifocal osteomyelitis, chronic
  • Chronic multifocal osteomyelitis
  • CMO
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.