Cold agglutinin disease
Other Names for this Disease
- Anemia, hemolytic, cold antibody
- Chronic cold agglutinin disease
- Cold agglutinin syndrome
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Cold agglutinin disease is typically classified as primary (unknown cause) or secondary (caused by an underlying condition). Secondary cold agglutinin disease may be associated with:
- Bacterial Infections such as mycoplasma, Legionnaires' disease, syphilis, listeriosis, or E. Coli
- Viral infections such Epstein-Barr virus, cytomegalovirus, mumps, varicella, rubella, adenovirus, HIV, influenza, or hepatitis C
- Parasitic infections such as malaria or trypanosomiasis
- Other autoimmune diseases such as systemic lupus erythematosus
- Certain types of cancers such as lymphoma, chronic lymphocytic leukemia, Waldenström macroglobulinemia, multiple myeloma, and Kaposi sarcoma
Last updated: 5/6/2015
- Salman Abdullah Aljubran, MD. Cold Agglutinin Disease. Medscape Reference. April 2015; http://emedicine.medscape.com/article/135327-overview.
- Stanley L Schrier, MD; Wendell F Rosse, MD. Clinical features and treatment of autoimmune hemolytic anemia: Cold agglutinins. UpToDate. December 2014; Accessed 5/5/2015.