Cold agglutinin disease
Other Names for this Disease
- Anemia, hemolytic, cold antibody
- Cold antibody disease
- Cold antibody hemolytic anemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.
On this page
Cold agglutinin disease is typically classified as primary (unknown cause) or secondary (caused by an underlying condition). Secondary cold agglutinin disease may be associated with:
- Bacterial Infections such as mycoplasma, Legionnaires' disease, syphilis, listeriosis, or E. Coli
- Viral infections such Epstein-Barr virus, cytomegalovirus, mumps, varicella, rubella, adenovirus, HIV, influenza, or hepatitis C
- Parasitic infections such as malaria or trypanosomiasis
- Other autoimmune diseases such as systemic lupus erythematosus
- Certain types of cancers such as lymphoma, chronic lymphocytic leukemia, Waldenström macroglobulinemia, multiple myeloma, and Kaposi sarcoma
Last updated: 5/6/2015
- Salman Abdullah Aljubran, MD. Cold Agglutinin Disease. Medscape Reference. April 2015; http://emedicine.medscape.com/article/135327-overview.
- Stanley L Schrier, MD; Wendell F Rosse, MD. Clinical features and treatment of autoimmune hemolytic anemia: Cold agglutinins. UpToDate. December 2014; Accessed 5/5/2015.