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Diseases

Genetic and Rare Diseases Information Center (GARD)

Common variable immunodeficiency


Other Names for this Disease
  • CVID
  • Common variable hypogamma-globulinemia
  • Hypogamma-globulinemia, acquired
  • Immunoglobulin deficiency, late-onset
  • Common variable immune deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies against agents that cause infection (such as bacteria). CVID is characterized by low levels of most or all of the immunoglobulin (Ig) classes. This causes affected people to get frequent infections, particularly in the sinuses, lungs, and digestive tract.[1] Symptoms most commonly begin in early adulthood but have been found in children as young as age two. While in most cases the cause of CVID is unknown, it has been associated with changes (mutations) in at least 10 genes.[2] About 10% of cases are due to mutations in the TNFRSF13B gene.[2] Treatment for CVID includes Ig replacement therapy, which stops the cycle of recurrent infections.[1]
Last updated: 3/14/2016

References

  1. Robert A Schwartz. Common Variable immunodeficiency. Medscape Reference. May 28, 2015; http://emedicine.medscape.com/article/1051103-overview.
  2. Common variable immune deficiency. Genetics Home Reference. July, 2014; http://ghr.nlm.nih.gov/condition/common-variable-immune-deficiency.
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Basic Information

  • The Immune Deficiency Foundation has an information page on this topic. Click on the link above to view the information page.
  • Genetics Home Reference (GHR) contains information on Common variable immunodeficiency. This website is maintained by the National Library of Medicine.
  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Common variable immunodeficiency. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • CVID
  • Common variable hypogamma-globulinemia
  • Hypogamma-globulinemia, acquired
  • Immunoglobulin deficiency, late-onset
  • Common variable immune deficiency
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.