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Diseases

Genetic and Rare Diseases Information Center (GARD)

Common variable immunodeficiency


Other Names for this Disease
  • Combined variable immune deficiency
  • Common variable hypogamma-globulinemia
  • Common variable immune deficiency
  • CVID
  • Hypogamma-globulinemia, acquired
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Overview

Common variable immunodeficiency (CVID) is a group of disorders in which the immune system cannot make antibodies in response to foreign substances that cause infection. The main feature that separates CVID from other immunodeficiencies is low levels of two specific antibodies, immunoglobulin A (IgA) and immunoglobulin G (IgG). People with CVID get more frequent infections, particularly in the sinuses, lungs, and digestive tract.[1][2] Symptoms most commonly begin in early adulthood but have been found in children as young as age two. While in most cases the cause of CVID is unknown, the condition has been associated with changes (mutations) in at least 10 genes.[3] About 10% of affected people have mutations in the TNFRSF13B gene.[3] The main treatment for CVID is Ig replacement therapy, which stops the cycle of recurrent infections.[4]
Last updated: 5/19/2015

References

  1. Primary Immunodeficiency. National Institute of Child Health and Human Development (NICHD) . April 7, 2008; http://www.nichd.nih.gov/publications/pubs/pages/primary_immuno.aspx#WhatisPrimaryImmunodeficiency. Accessed 10/12/2010.
  2. Schwartz RA, Modak RM, Modak P. Common Variable Immunodeficiency. eMedicine. March 16, 2010; http://emedicine.medscape.com/article/1051103-overview. Accessed 10/12/2010.
  3. Common variable immune deficiency. Genetics Home Reference. July, 2014; http://ghr.nlm.nih.gov/condition/common-variable-immune-deficiency. Accessed 9/15/2014.
  4. Robert A Schwartz. Common Variable immunodeficiency. Medscape Reference. May 27, 2014; http://emedicine.medscape.com/article/1051103-overview.
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Basic Information

  • The Immune Deficiency Foundation has an information page on this topic. Click on the link above to view the information page.
  • Genetics Home Reference (GHR) contains information on Common variable immunodeficiency. This website is maintained by the National Library of Medicine.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Common variable immunodeficiency. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Combined variable immune deficiency
  • Common variable hypogamma-globulinemia
  • Common variable immune deficiency
  • CVID
  • Hypogamma-globulinemia, acquired
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.