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Diseases

Genetic and Rare Diseases Information Center (GARD)

Cone-rod dystrophy 2


Other Names for this Disease
  • CORD2
  • Cone-rod retinal dystrophy 2
  • CRD2
  • Retinal cone-rod dystrophy 2
  • RCRD2
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

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How might cone-rod dystrophy 2 be treated? 

Although available treatment options for cone-rod dystrophy 2 (CORD2) cannot prevent or reverse vision loss, there are forms of intervention that may slow down the vision loss process or assist in maintaining activities of daily living. Interventions may include: low vision rehabilitation (orientation and mobility training, educational support, physical and occupational therapy), light avoidance, and sunglasses that block out green and blue. Avoidance of smoking and medications toxic to the retina such as Plaquenil can additionally be helpful. Nutritional supplements such as vitamin A, lutein, and omega-3 DHA have shown some benefits in similar disorders, such as retinitis pigmentosa and may be beneficial.[1][2]

Future prospects for therapy discussed in the medical literature include: gene therapy, stem cell therapy, and retinal implants. Efficacy of some of these options are being explored through clinical trials, while others are focused on animal studies.[3]
Last updated: 5/10/2016

References
  1. C. Hamel. Cone rod dystrophy. Orphanet. 2/2007; http://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=1843. Accessed 5/10/2016.
  2. Sahel JA, Marazova K, Audo I. Clinical characteristics and current therapies for inherited retinal degenerations. Cold Spring Harb Perspect Med. Oct 16, 2014; 5(2):http://www.ncbi.nlm.nih.gov/pubmed/25324231.
  3. Benjamin M. Nash, Dale C. Wright, John R. Grigg, Bruce Bennetts, Robyn V. Jamieson. Retinal dystrophies, genomic applications in diagnosis and prospects for therapy. Translational Pediatrics. April 2015; 4(2):139-163. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729094/.


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Cone-rod dystrophy 2. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • The U.S. National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. There is a study titled Screening Study for the Evaluation and Diagnosis of Potential Research Participants which may be of interest to you. To find this trial, click on the link above.
Other Names for this Disease
  • CORD2
  • Cone-rod retinal dystrophy 2
  • CRD2
  • Retinal cone-rod dystrophy 2
  • RCRD2
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.