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Diseases

Genetic and Rare Diseases Information Center (GARD)

Ligneous conjunctivitis


Other Names for this Disease
  • Conjunctivitis lignosa
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Overview

Ligneous conjunctivitis is a rare disorder characterized by the buildup of a protein called fibrin which causes inflammation of the conjunctiva (conjunctivitis) and leads to thick, woody (ligneous), inflamed growths that are yellow, white, or red. Ligneous conjunctivitis most often occurs on the inside of the eyelids, but may also affect the sclera, cornea and pupil, leading to vision loss.[1] A systemic form of the condition may occur, affecting the mucous membranes of the larynx, vocal chords, nose, trachea, bronchi, vagina, cervix, and gingiva. The cause of ligneous conjunctivitis is unknown. Autosomal recessive inheritance has been suggested in some cases.[2] Ligneous conjunctivitis is sometimes associated with a condition known as congenital plasminogen deficiency.
Last updated: 4/29/2013

References

  1. Congenital plasminogen deficiency. Genetics Home Reference (GHR). August 2012; http://ghr.nlm.nih.gov/condition/congenital-plasminogen-deficiency. Accessed 4/29/2013.
  2. Conjunctivitis, Ligneous. National Organiation for Rare Disorders (NORD). 2007; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/863/viewAbstract. Accessed 4/29/2013.
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Basic Information

  • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
Other Names for this Disease
  • Conjunctivitis lignosa
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.