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Diseases

Genetic and Rare Diseases Information Center (GARD)

Cramp-fasciculation syndrome


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Overview

Cramp-fasciculation syndrome (CFS) is a rare condition of the muscles. Affected people have persistent muscle twitching (fasciculations) and cramping, which can lead to muscle discomfort, pain, or tiredness. Muscles in the leg are most commonly affected, although this condition may involve several parts of the body. Symptoms are thought to be due to overactivity of the associated nerves. In most cases, CFS occurs sporadically in people with no family history of the condition. There is limited information about the treatment of CFS, but certain medications have been reported as beneficial in individual cases.[1][2][3]
Last updated: 7/14/2015

References

  1. Tahmoush AJ, Alonso RJ, Tahmoush GP, Heiman-Patterson TD. Cramp-fasciculation syndrome: a treatable hyperexcitable peripheral nerve disorder. Neurology. July 1991; 41(7):1021-1024.
  2. Shimatani Y, Nodera H, Shibuta Y, Miyazaki Y, Misawa S, Kuwabara S, Kaji R. Abnormal gating of axonal slow potassium current in cramp-fasciculation syndrome. Clin Neurophysiol. June 2015; 126(6):1246-1254.
  3. Liewluck T, Klein CJ, Jones LK Jr.. Cramp-fasciculation syndrome in patients with and without neural autoantibodies. Muscle Nerve. March 2014; 49(3):351-356.
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In Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Cramp-fasciculation syndrome. Click on the link to view a sample search on this topic.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.