Other Names for this Disease
- DW complex
- Dandy-Walker syndrome or malformation (type of DW complex)
- Dandy-Walker variant (type of DW complex)
- Mega cisterna magna (type of DW complex)
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 This condition may present with an increase in fluid and pressure around the skull (hydrocephalus). It may also be associated with developmental delay, or malformations of the heart, face, limbs, fingers, or toes. The term "Dandy-Walker complex" represents a spectrum of abnormalities that includes Dandy-Walker variant, Dandy-Walker malformation, and mega cisterna magna.Dandy-Walker complex is a congenital brain malformation involving the cerebellum (an area at the back of the brain that controls movement) and the fluid-filled spaces around it. This condition is characterized by an enlargement of the fourth ventricle (a small channel that allows fluid to flow freely between the upper and lower areas of the brain and spinal cord), a partial or complete absence of the cerebellar vermis (the area between the two cerebellar hemispheres), and cyst formation near the internal base of the skull.
Last updated: 1/7/2013
- NINDS Dandy-Walker Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). December 16, 2011; http://www.ninds.nih.gov/disorders/dandywalker/dandywalker.htm. Accessed 1/7/2013.
- Incesu L, Khosla A. Imaging in Dandy-Walker Malformation . Medscape Reference. May 2011; http://emedicine.medscape.com/article/408059-overview. Accessed 1/7/2013.
- Sasaki-Adams D, Elbabaa SK, Jewells V, Carter L, Campbell JW, Ritter AM. The Dandy-Walker variant: a case series of 24 pediatric patients and evaluation of associated anomalies, incidence of hydrocephalus, and developmental outcomes. J Neurosurg Pediatr. 2008; http://www.ncbi.nlm.nih.gov/pubmed?term=18759601. Accessed 1/7/2013.
- Genetics Home Reference contains information on Dandy-Walker complex. This website is maintained by the National Library of Medicine.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Dandy-Walker complex. Click on the link to view a sample search on this topic.