- Darier White Disease
- Darier's disease
- Keratosis follicularis
- Darier-White disease
Your QuestionI have had the diagnosis of Darier disease for many years. My skin has recently been getting worse. I'm looking for more information about treatment, research and how to find a dermatologist in my area who has experience with this condition.
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The affected skin may smell unpleasant, which may be due to bacteria growing in the rash. If bacterial overgrowth is suspected or there is a lot of crusting, it can be helpful to apply antiseptics or soak in astringents.
Topical medications may include topical retinoids (i.e., adapalene, tazarotene gel, or tretinoin). Topical retinoids may reduce hyperkeratosis within 3 months. However, irritation is a side effect. Other medications may include acitretin, isotretinoin, cyclosporine, or oral retinoids (eg, acitretin, isotretinoin). Oral retinoids have been the most effective medical treatment for Darier disease, leading to reduction of symptoms in 90% of affected people. However, prolonged use is limited due to adverse effects.
Other treatments may include oral antibiotics to clear bacterial infection, oral acyclovir to treat or suppress herpes simplex virus infection; dermabrasion; electrosurgery; and Mohs micrographic surgery for localized areas.
American Academy of Dermatology
930 E Woodfield Rd
Schaumburg, Illinois 60173-4729
Web site: http://www.aad.org/
The following organizations may be able to help you find a dermatologist who has had experience treating individuals with Darier disease.
Foundation for Ichthyosis and Related Skin Types
2616 N. Broad Street
Colmar, PA 18915
Web site: http://www.firstskinfoundation.org
Medical Advisory Board: http://www.firstskinfoundation.org/content.cfm/Ichthyosis/Medical-Scientific-Advisory-Board/page_id/739
Web page with Darier disease information: http://www.firstskinfoundation.org/content.cfm/Ichthyosis/Darier-Disease/page_id/544
American Skin Association, Inc.
346 Park Avenue South, 4th Floor
New York, NY 10010
Web site: http://www.americanskin.org/
- Darier disease. Genetics Home Reference. March 2008; http://ghr.nlm.nih.gov/condition=darierdisease. Accessed 3/6/2014.
- Amy Stanway. Darier disease. DermNet NZ. October 18, 2015; http://www.dermnetnz.org/scaly/darier.html.
- Goldsmith, Lowell A., Baden, Howard P.. Darier-White Disease (Keratosis Follicularis) and Acrokeratosis Verruciformis. In: edited by Freedberg, Eisen, Wolff, Austen, Goldsmith and Katz. Fitzpatrick's Dermatology in General Medicine, 6th edition. McGraw Hill Companies; 2003;
- Kwok PY, Fitzmaurice S. Darier disease. Medscape Reference. September 21, 2012; http://emedicine.medscape.com/article/1107340-overview. Accessed 3/6/2014.