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Diseases

Genetic and Rare Diseases Information Center (GARD)

Dubin-Johnson syndrome


Other Names for this Disease
  • DJS
  • Hyperbilirubinemia 2
  • Chronic Idiopathic Jaundice
  • Conjugated Hyperbilirubinemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

I have Dubin-Johnson syndrome. Can this condition be passed along to another individual through sexual intercourse?

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

What is Dubin-Johnson syndrome?

Dubin-Johnson syndrome (DJS) is an inherited disorder of bilirubin characterized by a by a buildup of bilirubin in the bloodstream (hyperbilirubinemia). When bilirubin builds up in the skin and the whites of the eyes, it can cause a yellowish color to the skin (jaundice). Individuals with DJS may also have a liver that is sometimes enlarged and tender.[1] The symptoms often do not present until puberty or adulthood. Factors that may worsen symptoms include: alcohol use, birth control bills, infection, and pregnancy. In most cases, treatment is not required.[2][3] 
Last updated: 6/17/2016

What causes Dubin-Johnson syndrome (DJS)?

DJS is a genetic disorder caused by mutations in the ABCC2 gene. The ABCC2 gene codes for a protein called multidrug resistance protein 2 (MRP2). MRP2 transports substances out of cells. It is primarily found in the liver, but can also be found in the kidneys, intestine, and placenta during pregnancy.[4]

Mutations in the ABCC2 gene affect the structure and function of the MRP2 protein. This may disrupt the body's ability to rid itself of bilirubin, resulting in a build up.[4] 
Last updated: 6/17/2016

How is Dubin-Johnson syndrome (DJS) inherited?

DJS is inherited in an autosomal recessive manner.[5] This means that to be affected, a person must have a mutation in both copies of the responsible gene in each cell. Affected people inherit one mutated copy of the gene from each parent, who is referred to as a carrier. Carriers of an autosomal recessive condition typically do not have any signs or symptoms (they are unaffected). When 2 carriers of an autosomal recessive condition have children, each child has a:
  • 25% (1 in 4) chance to be affected
  • 50% (1 in 2) chance to be an unaffected carrier like each parent
  • 25% (1 in 4) chance to be unaffected and not be a carrier
Last updated: 6/17/2016

Can Dubin-Johnsons syndrome (DJS) be passed along to another individual through sexual intercourse?

No, DJS is caused by a gene mutation that is passed down (inherited) through families.[1] It is not a contagious condition and cannot be passed along to another individual through sexual intercourse.
Last updated: 6/17/2016

References
Other Names for this Disease
  • DJS
  • Hyperbilirubinemia 2
  • Chronic Idiopathic Jaundice
  • Conjugated Hyperbilirubinemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.