Duchenne muscular dystrophy
- Muscular dystrophy, Duchenne
- Muscular dystrophy, pseudohypertrophic progressive, Duchenne type
Your QuestionSeveral members of my husband's family are carriers of Duchenne and Becker muscular dystrophy. My husband does not have the disease. What are the chances of passing on this condition to any children we may have?
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In about two thirds of cases, an affected male inherits the mutation from a mother who carries an altered copy of the DMD gene. The other one third of cases probably result from new mutations in the gene.
In X-linked recessive inheritance, a female with one mutated copy of the gene in each cell is called a carrier. She can pass on the altered gene, but usually does not experience signs and symptoms of the disorder. Occasionally, however, females who carry a DMD mutation may have muscle weakness and cramping. These symptoms are typically milder than the severe muscle weakness and atrophy seen in affected males. Females who carry a DMD mutation also have an increased risk of developing heart abnormalities including dilated cardiomyopathy.
Duchenne and Becker muscular dystrophy are inherited in an X-linked recessive manner. Because of the difference in sex chromosomes, the probability of passing on an X-linked recessive disorder also differs between men and women. The sons of a man with an X-linked recessive disorder will not be affected, and his daughters will carry one copy of the mutated gene (illustration). With each pregnancy, a woman who carries an X-linked recessive disorder has a 50 percent chance of having sons who are affected and a 50 percent chance of having daughters who carry one copy of the mutated gene (illustration).
Although the chances of inheriting a genetic condition appear straightforward, factors such as a person’s family history and the results of genetic testing can sometimes modify those chances. In addition, some people with a disease-causing mutation never develop any health problems or may experience only mild symptoms of the disorder. Estimating the chance of developing or passing on a genetic disorder can be complex. Genetics professionals can help people understand these chances and help them make informed decisions about their health.
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- Duchenne and Becker muscular dystrophy. Genetics Home Reference (GHR). 2007; http://www.ghr.nlm.nih.gov/condition=duchenneandbeckermusculardystrophy. Accessed 11/18/2009.
- If a genetic disorder runs in my family, what are the chances that my children will have the condition?. Genetics Home Reference (GHR). 2009; http://ghr.nlm.nih.gov/handbook/inheritance/riskassessment. Accessed 10/26/2009.