Other Names for this Disease
- Shulman syndrome
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About 10-20% of people with eosinophilic fasciitis recover spontaneously without treatment. For those who do not, glucocorticoids (0.5–1 mg/kg/d), such as prednisone, are the mainstay therapy. Even with treatment, improvement in symptoms can take weeks or months. Glucocorticoids are successful in treating eosionophilic fasciitis in over 70% of cases. If glucocorticoids are unsuccessful, methotrexate at low doses (15–25 mg once weekly) is probably the most favored second-line treatment, especially in people with reddish to purpleish (morphea-like) skin lesions. Other treatment options include NSAIDs, D-penicillamine, chloroquine, cimetidine, azathioprine, cyclosporin A, infliximab, UVA-1, and bath PUVA. Physical therapy may help improve joint mobility and decrease contractures. Surgical release has been used in some severe cases to manage significant joint contractures.
Last updated: 11/12/2015
- Danis R et al.,. Unusual presentation of eosinophilic fasciitis: two case reports and a review of the literature. J Med Case Reports. 2010; 4:46. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830980. Accessed 6/11/2015.
- Pinal-Fernandez I, Selva-O' Callaghan A, Grau JM. Diagnosis and classification of eosinophilic fasciitis. Autoimmun Rev. 2014 Apr-May; 13(4-5):379-82. Accessed 6/11/2015.
- Henning PM. Eosinophilic Fasciitis. Medscape Reference. March 2015; http://emedicine.medscape.com/article/329515-overview. Accessed 11/12/2015.
- ClinicalTrials.gov lists trials that are studying or have studied Eosinophilic fasciitis. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.