Epidermolysis bullosa acquisita
- EB acquisita
- Acquired epidermolysis bullosa
Your QuestionCan this cause dizziness? And can I transfer it to my kids? Is it genetic?
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Non-inflammatory or mildly inflammatory EBA affecting only trauma-prone skin (the "classic" form) may cause:
- tense, blood- or pus-filled blisters, mostly on the hands, knees, knuckles, elbows and ankles
- mucous-membrane blisters that rupture easily
- healing with significant scarring and small white spots (milia)
Generalized inflammatory EBA may cause:
- widespread blisters that are not localized to trauma-prone sites
- generalized redness and itching
- healing with minimal scarring
- blisters on various mucous membranes
- significant scarring and dysfunction
EBA affecting several family members has been reported, suggesting a genetic component may be involved in some cases. Rarely, people with lupus, a systemic autoimmune disease, develop a generalized blistering skin disease with the features of EBA. EBA has also been associated with Crohn's disease.
There have been a couple of reports of families with more than one affected person, suggesting a genetic component may be involved. This could mean that EBA may develop in a person who is "genetically susceptible." However, the condition is not thought to be due to any specific gene(s).
- Epidermolysis bullosa acquisita. DermNet NZ. December 29, 2013; http://www.dermnetnz.org/immune/epidermolysis-bullosa-acquisita.html. Accessed 2/27/2014.
- Gupta R, Woodley DT, Chen M. Epidermolysis bullosa acquisita. Clin Dermatol. January-February, 2012; 30(1):60-69. Accessed 3/3/2014.
- Jaggi Rao. Epidermolysis bullosa acquisita. Medscape Reference. April 5, 2013; http://emedicine.medscape.com/article/1063083-overview. Accessed 3/3/2014.
- Noe MH, Chen M, Woodley DT, Fairley JA. Familial epidermolysis bullosa acquisita. Dermatol Online J. December 15, 2008; 14(12):2. Accessed 3/3/2014.