- Primary erythermalgia
- Mitchell disease (formerly)
Your QuestionI suffer from erythromelalgia. I recently began to take gabapentin without much relief. Can this medication successfully treat erythromelalgia? What other treatment options are available?
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Questions on this page
- What is erythromelalgia?
- How might erythromelalgia be treated?
- Has gabapentin been used to successfully treat erythromelalgia?
- Where can I find more information about using gabapentin as a treatment for erythromelalgia?
- What new therapy for erythromelalgia may be of interest?
- How can I locate additional medical articles about treatment for erythromelalgia?
Drugs shown to be effective in relieving pain in some individuals include: aspirin, prostaglandins (misoprostol), serotonin-norepinephrine reuptake inhibitors (venlafaxine and sertraline) and selective serotonin reuptake inhibitors (SSRIs), anticonvulsants (gabapentin), sodium channel blockers, carbamazepine, tricyclic antidepressants (amitriptyline and imipramine), calcium antagonists (nifedipine and diltiazem), magnesium, sodium nitroprusside infusion, and cyclosporine. Other treatments include: cooling or elevating the extremity, topical treatment with capsaicin cream, and surgical sympathectomy (a procedure where the sympathetic nerve fibers are selectively cut).Avoidance of triggers (such as warmth, prolonged standing, etc.) may reduce the number or severity of flare ups. 
You can find relevant journal articles on treatment for erythromelalgia through a service called PubMed, a searchable database of medical literature. Information on finding an article and its title, authors, and publishing details is listed here. Some articles are available as a complete document, while information on other studies is available as a summary abstract. To obtain the full article, contact a medical/university library (or your local library for interlibrary loan), or order it online using the following link. Using "treatment AND erythromelalgia" as your search term should locate articles. To narrow your search, click on the “Limits” tab under the search box and specify your criteria for locating more relevant articles. Click here to view a search.
- Erythromelalgia. DermNet NZ. July 1, 2011; http://dermnetnz.org/vascular/erythromelalgia.html. Accessed 12/11/2013.
- Erythromelalgia. Genetics Home Reference. November, 2012; http://ghr.nlm.nih.gov/condition=erythromelalgia. Accessed 12/11/2013.
- Hisma FM, Dib-Hajj SD, Waxman SG. SCN9A-Related Inherited Erythromelalgia. Gene Reviews. August 15, 2013; http://www.ncbi.nlm.nih.gov/books/NBK1163/.
- Erythromelalgia. DermNet. 2009; http://dermnetnz.org/vascular/erythromelalgia.html. Accessed 8/17/2011.
- Ljubojevic S, Lipozencic J, Pustisek N. Acta Dermatovenerol Croat. 2004; http://www.ncbi.nlm.nih.gov/pubmed/15075045. Accessed 4/1/2009.
- Jaqustyn P, Romaniak A. Neurol Neurochir Pol. 2002; http://www.ncbi.nlm.nih.gov/pubmed/12523121. Accessed 4/1/2009.
- Nathan A, Rose JB, Guite JW, Hehir D, Milovich K. Pediatrics. 2005; http://www.ncbi.nlm.nih.gov/pubmed/15741349. Accessed 4/1/2009.
- Gabapentin. MedlinePlus. March 1, 2009; http://www.nlm.nih.gov/medlineplus/druginfo/meds/a694007.html. Accessed 4/1/2009.