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Diseases

Genetic and Rare Diseases Information Center (GARD)

Erythromelalgia


Other Names for this Disease
  • Primary erythermalgia
  • Mitchell disease (formerly)
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Treatment

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How might erythromelalgia be treated?

There appear to be several subtypes of erythromelalgia and different subtypes respond to different therapies. Treatment consists of a trying various approaches until the best therapy is found.[1] Patients respond quite variably to drug therapy and no single therapy has proved consistently effective. Spontaneous remissions have also been known to occur.[2]

Drugs shown to be effective in relieving pain in some individuals include: aspirin, prostaglandins (misoprostol), serotonin-norepinephrine reuptake inhibitors (venlafaxine and sertraline) and selective serotonin reuptake inhibitors (SSRIs), anticonvulsants (gabapentin), sodium channel blockers, carbamazepine, tricyclic antidepressants (amitriptyline and imipramine), calcium antagonists (nifedipine and diltiazem), magnesium, sodium nitroprusside infusion, and cyclosporine. Other treatments include: cooling or elevating the extremity, topical treatment with capsaicin cream, and surgical sympathectomy (a procedure where the sympathetic nerve fibers are selectively cut).Avoidance of triggers (such as warmth, prolonged standing, etc.) may reduce the number or severity of flare ups. [1][2]

Last updated: 7/25/2016

References
  1. Hisma FM, Dib-Hajj SD, Waxman SG. SCN9A-Related Inherited Erythromelalgia. Gene Reviews. August 15, 2013; http://www.ncbi.nlm.nih.gov/books/NBK1163/.
  2. Erythromelalgia. DermNet. 2009; http://dermnetnz.org/vascular/erythromelalgia.html. Accessed 8/17/2011.


Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Erythromelalgia. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • Primary erythermalgia
  • Mitchell disease (formerly)
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.