Factor V Leiden thrombophilia
- Hereditary resistance to activated protein C
- APC resistance, Leiden type
Your QuestionI have factor V Leiden and was wondering if it's safe to use oral contraceptives. I want to take the pill called Levlin.
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According to the practice guidelines set forth by the American College of Obstetrics and Gynecology, women with familial thrombophilic syndromes, including factor V Leiden mutation, have an increased risk of venous thromboembolism during oral contraceptive use and also developing venous thromboembolism earlier during use than lower risk users. An initial study concluded that women with a factor V Leiden mutation had an eight-fold increased risk of venous thromboembolism than did women without the mutation. The risk was more than 30 times higher in carriers who used oral contraceptives than in non-oral contraceptive users who were not carriers of the mutation. However, most of these women will never experience venous thromboembolism, even if they used combination oral contraceptives.You can find a list of brand names of oral contraceptives at the following link from MedlinePlus, the National Library of Medicine Web site designed to help you research your health questions.
The following online resources can help you find a genetics professional in your community:
- The National Society of Genetic Counselors provides a searchable directory of US and international genetic counseling services.
- The American College of Medical Genetics has a searchable database of US genetics clinics.
- The University of Kansas Medical Center provides a list of US and international genetic centers, clinics, and departments.
- The American Society of Human Genetics maintains a database of its members, which includes individuals who live outside of the United States. Visit the link to obtain a list of the geneticists in your country, some of whom may be researchers that do not provide medical care.
- ACOG Committee on Practice Bulletins-Gynecology. ACOG practice bulletin. No. 73: Use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2006; 107(6):1453-72. http://www.ncbi.nlm.nih.gov/pubmed/16738183. Accessed 9/8/2011.