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Diseases

Genetic and Rare Diseases Information Center (GARD)

Factor V Leiden thrombophilia

*

* Not a rare disease

Other Names for this Disease
  • Hereditary resistance to activated protein C
  • APC resistance, Leiden type
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Your Question

I have factor V Leiden and was wondering if it's safe to use oral contraceptives. I want to take the pill called Levlin.

Our Answer

We have identified the following information that we hope you find helpful. If you still have questions, please contact us.

Is it safe for someone with factor V Leiden to use oral contraceptives?

In general, it is widely accepted that in women with factor V Leiden, hormones such as oral contraceptives and hormone replacement therapy increases the risk of blood clots. We strongly recommend you speak with your doctor about the risks and benefits of taking any sort of contraceptive or hormone replacement therapy.

According to the practice guidelines set forth by the American College of Obstetrics and Gynecology, women with familial thrombophilic syndromes, including factor V Leiden mutation, have an increased risk of venous thromboembolism during oral contraceptive use and also developing venous thromboembolism earlier during use than lower risk users. An initial study concluded that women with a factor V Leiden mutation had an eight-fold increased risk of venous thromboembolism than did women without the mutation. The risk was more than 30 times higher in carriers who used oral contraceptives than in non-oral contraceptive users who were not carriers of the mutation. However, most of these women will never experience venous thromboembolism, even if they used combination oral contraceptives.[1]

You can find a list of brand names of oral contraceptives at the following link from MedlinePlus, the National Library of Medicine Web site designed to help you research your health questions.
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a601050.html#brand-name-2
Last updated: 9/8/2011

How can I find a hematologist in my community?

The American Society of Hematology has a tool on their Web site to help patients find a hematologist in their area. You can search by location and specialty, such as thrombosis and blood clotting. You can click on the link below to view this search tool.
http://store.hematology.org/Default.aspx?tabid=231
Last updated: 9/8/2011

How can I find a genetics professional in my area?

To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Online directories are provided by GeneTests, the American College of Medical Genetics, and the National Society of Genetic Counselors. If you need additional help, contact a GARD Information Specialist. You can also learn more about genetic consultations from Genetics Home Reference.
Last updated: 7/15/2016

References
  • ACOG Committee on Practice Bulletins-Gynecology. ACOG practice bulletin. No. 73: Use of hormonal contraception in women with coexisting medical conditions. Obstet Gynecol. 2006; 107(6):1453-72. http://www.ncbi.nlm.nih.gov/pubmed/16738183. Accessed 9/8/2011.
Other Names for this Disease
  • Hereditary resistance to activated protein C
  • APC resistance, Leiden type
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.