Factor V Leiden thrombophilia
- Hereditary resistance to activated protein C
- APC resistance, Leiden type
Factor V Leiden increases the risk of developing a DVT during pregnancy by about seven-fold. Women with factor V Leiden who are planning pregnancy should discuss this with their obstetrician and/or hematologist. Most women with factor V Leiden have normal pregnancies and only require close follow-up during pregnancy. For those with a history of DVT or PE, treatment with an anticoagulant during a subsequent pregnancy can prevent recurrent problems. 
- Learning About Factor V Leiden Thrombophilia. National Human Genome Research Institute (NHGRI). December 2010; http://www.genome.gov/15015167. Accessed 3/18/2011.
- GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.