Factor X deficiency
Other Names for this Disease
- F10 deficiency
- Factor X deficiency, congenital
- Stuart factor deficiency, congenital
- Stuart-Prower factor deficiency
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miscarriages. Acquired (non-inherited) factor X deficiency, which is the most common form of the condition, generally occurs sporadically in people with no family history of the condition. Acquired factor X deficiency has a variety of causes including liver disease, vitamin K deficiency, exposure to certain medications that affect clotting, and cancers. The inherited form of factor X deficiency (also called congenital factor X deficiency) is caused by changes (mutations) in the F10 gene and is inherited in an autosomal recessive manner. Treatment aims to control bleeding through intravenous (IV) infusions of plasma or concentrates of clotting factors.Factor X deficiency is a rare condition that affects the blood's ability to clot. The severity of the condition and the associated signs and symptoms can vary significantly from person to person. Common features of factor X deficiency may include easy bruising, frequent nosebleeds, bleeding gums, blood in the urine, and prolonged bleeding after minor injuries. Affected women may also experience heavy menstrual bleeding and may have an increased risk for first trimester
Last updated: 11/12/2015
- Robert A Schwartz, MD, MPH. Factor X Deficiency. Medscape Reference. November 2015; http://emedicine.medscape.com/article/209867-overview.
- Factor X deficiency. MedlinePlus. January 2015; https://www.nlm.nih.gov/medlineplus/ency/article/000553.htm.
- Factor X deficiency. Genetics Home Reference. January 2015; http://ghr.nlm.nih.gov/condition/factor-x-deficiency.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Factor X deficiency. Click on the link to view a sample search on this topic.