Primary Familial Brain Calcification
Other Names for this Disease
- Bilateral striopallidodentate calcinosis
- Cerebral calcification nonarteriosclerotic idiopathic adult-onset
- Cerebrovascular ferrocalcinosis
- Fahr disease, familial (formerly)
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neurodegenerative disorder characterized by calcium deposits in the basal ganglia, a part of the brain that helps start and control movement. The first symptoms often include clumsiness, fatigue, unsteady walking (gait), slow or slurred speech, difficulty swallowing (dysphagia) and dementia. Seizures of various types frequently occur. Symptoms typically start in an individual's 20's to 40's but may begin at any age.The neuropsychiatric symptoms and movement disorders worsen over time. Mutations in the SLC20A2 and PDGFRB genes have been found to cause FIBGC, and this condition is inherited in an autosomal dominant manner.Familial idiopathic basal ganglia calcification (FIBGC) is a
Last updated: 10/18/2013
- Sobrido MJ, Coppola G, Oliveira J, Hopfer S, Geschwind DH. Familial Idiopathic Basal Ganglia Calcification. GeneReviews. June 27, 2013; http://www.ncbi.nlm.nih.gov/books/NBK1421/. Accessed 10/18/2013.
- Familial idiopathic basal ganglia calcification. Genetics Home Reference (GHR). February 2013; http://ghr.nlm.nih.gov/condition/familial-idiopathic-basal-ganglia-calcification. Accessed 10/18/2013.
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