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Diseases

Genetic and Rare Diseases Information Center (GARD)

Fibrous dysplasia


Other Names for this Disease
  • Fibrous dysplasia of bone
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Treatment

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How might fibrous dysplasia be treated?

Unfortunately, there is no cure for fibrous dysplasia.[1]  Treatment of fibrous dysplasia depends on the symptoms that develop.  Surgery can often treat broken bones or significant bone malformations, though problems can recur and multiple procedures may be needed.[2][3]  A group of medications known as bisphosphonates has been shown to relieve bone pain in both adults and children.[4]  In adults only, these medications have also been shown to strengthen normal bone by preventing it from being replaced by weaker tissues or by increasing the thickness of the bone (density).  These medications have not been shown to prevent fractures or bone malformations.[5]  Calcium and vitamin D supplements may also be considered to help promote bone health.[6]  Radiotherapy is not recommended because it is associated with an increased risk of fibrous dysplasia becoming cancerous.[2][7][3]  Careful, long-term follow-up to monitor fibrous dysplasia is advised, particularly during pregnancy because the lesions may progress more rapidly during this period.[2][3]
Last updated: 8/25/2011

References
  1. Kaneshiro NK, Zieve D. Fibrous dysplasia. MedlinePlus. 08/02/2011; http://www.nlm.nih.gov/medlineplus/ency/article/001234.htm. Accessed 8/23/2011.
  2. Merchant SN, Nadol JB Jr. Otologic manifestations of systemic disease. In: Cummings CW et al., eds. Otolaryngology: Head & Neck Surgery, 4th ed. Philadelphia, PA: Mosby, Inc; 2005;
  3. Feske SK, Cochrane TI. Degenerative and compressive structural disorders. In: Goetz CG. Textbook of Clinical Neurology, 3rd ed. Philadelphia PA: Sunders; 2007;
  4. Plotkin H, Rauch F, Zeitlin L, Munns C, Travers R, Glorieux FH. Effect of pamidronate treatment in children with polyostotic fibrous dysplasia of bone. Journal of Clinical Endocrinology and Metabolism. 2003; 88:4569-4575. http://www.ncbi.nlm.nih.gov/pubmed/14557424. Accessed 8/23/2011.
  5. Silverman SL. Bisphosphonate use in conditions other than osteoporosis. Annals of the New York Academy of Sciences. 2011; 1218:33-37. http://www.ncbi.nlm.nih.gov/pubmed/20946575. Accessed 8/23/2011.
  6. Chapurlat RD, Meunier PJ. Fibrous dysplasia of the bone. Bailliere's Best Practices & Research. Clinical Rheumatology. 2000; 14:385-398. http://www.ncbi.nlm.nih.gov/pubmed/10925751. Accessed 8/23/2011.
  7. Rosenberg AE. Bones, joints, and soft tissue tumors. In: Kumar V et al., eds. Pathologic Basis of Disease, 7th ed. Philadelphia PA: Saunders; 2005;


GARD Video Tutorial

  • Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.

    Finding Treatment Information

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Fibrous dysplasia. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • Orphanet lists European clinical trials, research studies, and patient registries enrolling people with this condition. 
Other Names for this Disease
  • Fibrous dysplasia of bone
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.