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Diseases

Genetic and Rare Diseases Information Center (GARD)

Gardner-Diamond syndrome


Other Names for this Disease
  • Autoerythrocyte sensitization
  • Psychogenic purpura
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Autoerythrocyte sensitization syndrome
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Cause

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What causes Gardner-Diamond syndrome?

The underlying cause of Gardner-Diamond syndrome (GDS) is poorly understood and has not been identified. Experts have proposed several possible explanations including:[1]
  • response to stress - stress, or distress, is associated with increased levels of glucocorticoids and catecholamines in the body, which may alter processes such as fibrinolysis (the breakdown of blood clots)
  • increased fibrinolysis - an increase in the activity of tissue plasminogen activator (tPA), which can cause a cascade of events that may lead to bleeding
  • autoerythrocyte sensitization - an autoimmune reaction to the affected person's own red blood cells (erythrocytes)
Last updated: 1/27/2016

References
  1. Benjamin P Geisler, Bruce J Dezube. Psychogenic purpura (Gardner-Diamond syndrome). UpToDate. Waltham, MA: UpToDate; December, 2015;


Other Names for this Disease
  • Autoerythrocyte sensitization
  • Psychogenic purpura
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Autoerythrocyte sensitization syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.