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Diseases

Genetic and Rare Diseases Information Center (GARD)

Gardner-Diamond syndrome


Other Names for this Disease
  • Autoerythrocyte sensitization
  • Psychogenic purpura
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Autoerythrocyte sensitization syndrome
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Treatment

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How might Gardner-Diamond syndrome be treated?

There is no specific treatment for Gardner-Diamond syndrome (GDS).[1] It has been suggested that psychiatric treatment (including psychotherapy) is the only reasonable therapeutic option.[2] In some people, psychiatric medications for mental illness have helped to improve the symptoms. For example, in a person with GDS and an underlying personality disorder, medications used to treat the personality disorder may help with the symptoms of GDS.[3] Due to the presumed psychological nature of the disease, placebo effect has been used successfully to ease the severity of symptoms.[1]

It has been proposed that certain medications used to alter the tonus of the capillaries (how they contract), the permeability of the vessels, and/or the flowing properties of the blood may be useful for some people.[3]

Symptomatic therapy may be helpful for severe, general symptoms. Several approaches including antihistamines, corticosteroids, antidepressants, hormones, and vitamins have had variable success.[1]
Last updated: 1/27/2016

References
  1. Jafferany M, Bhattacharya G. Psychogenic Purpura (Gardner-Diamond Syndrome). Prim Care Companion CNS Disord. January 22, 2015; 17(1):
  2. Benjamin P Geisler, Bruce J Dezube. Psychogenic purpura (Gardner-Diamond syndrome). UpToDate. Waltham, MA: UpToDate; December, 2015;
  3. OL Ivanov, AN Lvov, AV Michenko, J Künzel, P Mayser, U Gieler. Autoerythrocyte sensitization syndrome (Gardner–Diamond syndrome): review of the literature. Journal of the European Academy of Dermatology and Venereology. 2009; 23(5):499-504.


Other Names for this Disease
  • Autoerythrocyte sensitization
  • Psychogenic purpura
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Autoerythrocyte sensitization syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.