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Diseases

Genetic and Rare Diseases Information Center (GARD)

Gardner-Diamond syndrome


Other Names for this Disease
  • Autoerythrocyte sensitization
  • Psychogenic purpura
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Autoerythrocyte sensitization syndrome
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Symptoms

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What are the signs and symptoms of Gardner-Diamond syndrome?

People with Gardner-Diamond syndrome have reported that bruises occur either spontaneously or after trauma or surgery (even at other sites of the body). Some people are able to pinpoint exactly when the bruising occurred, while others are not.[1]

Episodes of bruising may begin with sensations such as burning, stinging or pain, and may be accompanied by a general feeling of malaise or fatigue.[1][2] This may be followed by warmth, puffiness, redness and/or itching over the affected area. In some cases, episodes may also be accompanied by fever, headache, or gastrointestinal symptoms. Sometimes, pain and swelling is severe enough to cause immobilization of the affected body part. People have reported that the pain generally subsides when the bruises appear.[1]

Bruises typically go away in approximately 7-10 days.[2] However, relapses and remissions of bruising episodes can last for many years. In some cases, symptoms of the condition persist and may worsen. Subsequent episodes are most likely to occur after some sort of physical trauma or stress.[2]
Last updated: 1/27/2016

References
  1. Benjamin P Geisler, Bruce J Dezube. Psychogenic purpura (Gardner-Diamond syndrome). UpToDate. Waltham, MA: UpToDate; December, 2015;
  2. OL Ivanov, AN Lvov, AV Michenko, J Künzel, P Mayser, U Gieler. Autoerythrocyte sensitization syndrome (Gardner–Diamond syndrome): review of the literature. Journal of the European Academy of Dermatology and Venereology. 2009; 23(5):499-504.


Other Names for this Disease
  • Autoerythrocyte sensitization
  • Psychogenic purpura
  • Autoerythrocyte sensitization purpura
  • Painful bruising syndrome
  • Autoerythrocyte sensitization syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.