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Diseases

Genetic and Rare Diseases Information Center (GARD)

Pemphigoid gestationis


Other Names for this Disease
  • Gestational pemphigoid
  • Herpes gestationis
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Overview

Pemphigoid gestationis (PG) is a pregnancy-associated autoimmune skin disorder. It usually begins abruptly during the 2nd or 3rd trimester of pregnancy, but can occur any time during pregnancy. Signs and symptoms often include the formation of very itchy, red bumps and/or blisters on the abdomen and trunk, but other parts of the body can be affected. Unrelenting itchiness (pruritus) often interferes with daily activities.[1] Symptoms may improve at the end of pregnancy, but flares may occur during, or right after, delivery. While it usually goes away on its own within weeks to months after delivery, it may recur during menses; with use of oral contraceptives; and/or with subsequent pregnancies.[1] PG is caused by a woman's immune system mistakenly attacking her own skin, but the exact reasons why this occurs is poorly understood. Treatment depends on severity and may include topical corticosteroids; oral corticosteroids, and/or oral antihistamines to relieve itching.[2]
Last updated: 5/3/2016

References

  1. Anatoli Freiman. Pemphigoid Gestationis. Medscape Reference. August 17, 2015; http://emedicine.medscape.com/article/1063499-overview.
  2. Vanessa Ngan. Pemphigoid gestationis. DermNet NZ. April 25, 2016; http://www.dermnetnz.org/immune/pemphigoid-gestationis.html.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Merck Manual for health care professionals provides information on Pemphigoid gestationis.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Pemphigoid gestationis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Gestational pemphigoid
  • Herpes gestationis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.