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Diseases

Genetic and Rare Diseases Information Center (GARD)

Gianotti Crosti syndrome


Other Names for this Disease
  • Acrodermatitis, infantile lichenoid
  • Acrodermatitis, papular infantile
  • Crosti-gianotti syndrome
  • GCS
  • PAC
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Overview

Gianotti Crosti syndrome (GCS) is a rare childhood skin condition characterized by a papular rash with blisters on the skin of the legs, buttocks, and arms. It typically affects children between 9 months and 9 years of age. Skin lesions typically last at least 10 days and often last for several weeks. The lesions are usually preceded by an underlying infection (usually a virus), which may cause associated symptoms such as low-grade fever, sore throat, or symptoms of an upper respiratory infection. When GCS is associated with hepatitis B, Epstein-Barr, or cytomegalovirus (CMV) infection, acute hepatitis may also occur. GCS is thought to be a hypersensitive response to the underlying infection. While in many countries the underlying cause is hepatitis B, this is rarely the cause in North America. GCS typically does not require treatment and goes away on its own within 1 to 3 months.[1][2] In some cases, a mild topical steroid cream may be prescribed to relieve itching.[3]
Last updated: 9/26/2015

References

  1. Gianotti Crosti Syndrome. NORD. 2009; http://rarediseases.org/rare-diseases/gianotti-crosti-syndrome/.
  2. Sören A Craig-Müller. Gianotti-Crosti Syndrome. Medscape Reference. August 1, 2014; http://emedicine.medscape.com/article/911275-overview.
  3. Amanda Oakley. Infantile papular acrodermatitis. DermnetNZ. September 19, 2015; http://dermnetnz.org/viral/gianotti-crosti.html.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
Other Names for this Disease
  • Acrodermatitis, infantile lichenoid
  • Acrodermatitis, papular infantile
  • Crosti-gianotti syndrome
  • GCS
  • PAC
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.