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Diseases

Genetic and Rare Diseases Information Center (GARD)

Granuloma annulare


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Treatment

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How might granuloma annulare be treated?

Granuloma annulare is difficult to treat and there are a limited number of clinical trials to reliably inform patients and physicians of the treatment options. Fortunately, most lesions of granuloma annulare disappear with no treatment within two years. Sometimes, however, the rings can remain for many years.[1] Very strong topical steroid creams or ointments may be used to speed the disappearance of the lesions. Injections of steroids directly into the rings may also be effective. Some physicians may choose to freeze the lesions with liquid nitrogen. In severe cases, ultraviolet light therapy (PUVA) or oral medications may be needed.[2]

Other treatments that have been tried include [1][3]:

 

  • Dapsone (a type of antibiotic) for widespread granuloma annulare 
  • Etretinate (not available in the US) 
  • Chloroquine 
  • Cyclosporine 
  • Niacinamide 
  • Oral psoralen 
  • Vitamin E combined with a 5-lipoxygenase inhibitor 
  • Fumaric acid esters 
  • Topical tacrolimus 
  • Pimecrolimus 
  • Infliximab (in a patient with disseminated granuloma annulare that did not respond to other treatments)

A review article titled, 'Diagnosis and Management of Granuloma Annulare' provides additional information on treatment options for granuloma annulare: http://www.aafp.org/afp/20061115/1729.html 

Also, an article from Medscape Reference provides information on treatment for granuloma annulare at the following link. You may need to register to view the article, but registration is free.
http://emedicine.medscape.com/article/1123031-overview

Last updated: 5/31/2013

References
  1. PR Cyr. Diagnosis and Management of Granuloma Annulare. American Family Physician. 2006; 74 (10): 1729-1734..
  2. Moskowitz RJ, Zieve D. Granuloma Annulare. MedlinePlus. July 30, 2014; http://www.nlm.nih.gov/medlineplus/ency/article/000833.htm. Accessed 10/9/2015.
  3. Freedberg, Irwin, et. al.. Fitzpatrick's Dermatology in General Medicine, 6th edition. United States: The McGraw-Hill Companies, Inc.; 2003;


Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Granuloma annulare. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.