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Diseases

Genetic and Rare Diseases Information Center (GARD)

Growth hormone deficiency


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Overview

Growth hormone deficiency (GHD) is characterized by abnormally short height due to lack (or shortage) of growth hormone. It can be congenital (present at birth) or acquired. Most cases are identified in children. Although it is uncommon, growth hormone deficiency may also be diagnosed in adults.[1] Too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults.[2] Most of the time, no single clear cause can be identified but several genetic causes of GHD have been described, such as mutations in the to POU1F1/Pit1 , PROP1 GHRH and GH1 genes.[3] In adolescents, puberty may be delayed or absent. Treatment involves growth hormone injections.[1]

Last updated: 6/3/2016

References

  1. Growth hormone deficiency - children. MedlinePlus. 2015; http://www.nlm.nih.gov/medlineplus/ency/article/001176.htm.
  2. Growth hormone test. MedlinePlus. 2014; http://www.nlm.nih.gov/medlineplus/ency/article/003706.htm.
  3. Richmond EJ & Rogol AD. Diagnosis of growth hormone deficiency in children. UpToDate. May 2016; http://www.uptodate.com/contents/diagnosis-of-growth-hormone-deficiency-in-children.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.