Factor XII deficiency
Other Names for this Disease
- HAF deficiency
- Hageman factor deficiency
- F12 deficiency
- Coagulation factor 12 deficiency
- Factor 12 deficiency
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 Factor XII deficiency is caused by mutations in the F12 gene. It is inherited in an autosomal recessive manner.Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. While a lack of factor XII does not cause affected individuals to bleed abnormally, the blood takes longer than normal to clot in a test tube. The condition is usually discovered when prolonged clotting is noticed in the process of running other laboratory tests.
Last updated: 6/24/2011
- Dugdale DC, Chen YB. Factor XII (Hageman factor) deficiency. MedlinePlus. 2011; http://www.nlm.nih.gov/medlineplus/ency/article/000545.htm. Accessed 6/24/2011.
- Factor XII Deficiency. Online Mendelian Inheritance in Man (OMIM). 2010; http://www.ncbi.nlm.nih.gov/omim/234000. Accessed 6/24/2011.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- MeSH® (Medical Subject Headings) is a terminology tool used by the National Library of Medicine. Click on the link to view information on this topic.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Factor XII deficiency. Click on the link to view a sample search on this topic.