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Diseases

Genetic and Rare Diseases Information Center (GARD)

Hemophilia A


Other Names for this Disease
  • Classic hemophilia
  • Classical hemophilia
  • Factor 8 deficiency
  • Factor VIII deficiency
  • Haemophilia A
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Overview

Hemophilia A is a bleeding disorder in which the blood does not clot normally. People with this disorder have prolonged bleeding or oozing after an injury, surgery, or tooth extraction. In severe cases, heavy bleeding occurs after minor injury or even when there is no injury (spontaneous bleeding). Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. In milder forms there is no spontaneous bleeding, and the disorder may not become apparent until after a surgery or serious injury. Hemophilia A is inherited in an X-linked recessive manner and is caused by changes (mutations) in the F8 gene.[1] The main treatment is called replacement therapy, during which clotting factor VIII is dripped or injected into a vein.[2]
Last updated: 3/18/2015

References

  1. Hemophilia. Genetics Home Reference. August, 2012; http://ghr.nlm.nih.gov/condition=hemophilia. Accessed 3/18/2015.
  2. How is hemophilia treated?. NHLBI. July 31, 2013; http://www.nhlbi.nih.gov/health/health-topics/topics/hemophilia/treatment.
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Basic Information

  • The American Society of Gene & Cell Therapy provides information on the treatment of hemophilia.
  • Genetics Home Reference (GHR) contains information on Hemophilia A. This website is maintained by the National Library of Medicine.
  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
  • The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers. 
  • The National Heart, Lung, and Blood Institute (NHLBI) provides leadership for a national program in diseases of the heart, blood vessels, lung, and blood; blood resources; and sleep disorders. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative. Click on the link to view information on this topic.
  • The National Human Genome Research Institute's (NHGRI) mission encompasses a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. Click on the link to view the information page on this topic.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hemophilia A. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Classic hemophilia
  • Classical hemophilia
  • Factor 8 deficiency
  • Factor VIII deficiency
  • Haemophilia A
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.