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Diseases

Genetic and Rare Diseases Information Center (GARD)

Hereditary pancreatitis


Other Names for this Disease
  • Hereditary chronic pancreatitis
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Overview

Hereditary pancreatitis is a rare genetic condition that causes multiple episodes of pancreatitis. The first episode of pancreatitis usually occurs in late childhood. Signs and symptoms may include stomach pain, fever, nausea, or vomiting. Episodes often lasts from one to three days, but may be longer. Repeat episodes of pancreatitis leads to chronic pancreatitis (a constantly inflamed pancreas), calcium deposits in the pancreas, and over years, pancreas scarring. At this stage signs and symptoms may include fatty stool, weight loss, and protein and vitamin deficiencies. People with hereditary pancreatitis are also at an increased risk for type 1 diabetes and pancreatic cancer, typically in adulthood. In most cases, hereditary pancreatitis is caused by mutations in the PRSS1 gene and passed through families in an autosomal dominant pattern.[1] While there is not a cure for hereditary pancreatitis, treatments are available (visit the Pancreas Foundation to learn more about treatment). With treatment people with hereditary pancreatitis tend to have a normal life expectancy.[1] 
Last updated: 1/20/2016

References

  1. Hereditary Pancreatitis. Genetics Home Reference. October 2012; http://ghr.nlm.nih.gov/condition/hereditary-pancreatitis. Accessed 1/20/2016.
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Basic Information

In Depth Information

  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Hereditary pancreatitis. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Hereditary chronic pancreatitis
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.