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Diseases

Genetic and Rare Diseases Information Center (GARD)

Hereditary spastic paraplegia


Other Names for this Disease
  • HSP
  • Familial spastic paraparesis
  • FSP
Related Diseases
  • Hereditary spastic paraplegia - autosomal dominant inheritance
  • Hereditary spastic paraplegia - autosomal recessive inheritance
  • Hereditary spastic paraplegia – maternal inheritance
  • Hereditary spastic paraplegia - X-linked inheritance
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Treatment

Newline Maker

How might hereditary spastic paraplegia (HSP) be treated?

There are no specific treatments to prevent, slow, or reverse HSP. Treatment is symptomatic and supportive. Medications may be considered for spasticity and urinary urgency. Regular physical therapy is important for muscle strength and to preserve range of motion.[1][2][3]
Last updated: 4/25/2016

References
  1. About HSP (Hereditary Spastic Paraplegia). Spastic Paraplegia Foundation, Inc.. 2016; http://sp-foundation.org/understanding-pls-hsp/hsp.html.
  2. Fink J. Hereditary Spastic Paraplegia Overview. GeneReviews. February 6, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1509/.
  3. NINDS Hereditary Spastic Paraplegia Information Page. National Institute of Neurological Disorders and Stroke (NINDS). February 10, 2014; http://www.ninds.nih.gov/disorders/hereditary_spastic_paraplegia/hereditary_spastic_paraplegia.htm.


GARD Video Tutorial

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Management Guidelines

  • GeneReviews provides current, expert-authored, peer-reviewed, full-text articles describing the application of genetic testing to the diagnosis, management, and genetic counseling of patients with specific inherited conditions.

Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Hereditary spastic paraplegia. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
  • The Research Portfolio Online Reporting Tool (RePORT) provides access to reports, data, and analyses of research activities at the National Institutes of Health (NIH), including information on NIH expenditures and the results of NIH-supported research. Although these projects may not conduct studies on humans, you may want to contact the investigators to learn more. To search for studies, enter the disease name in the "Text Search" box. Then click "Submit Query".
Other Names for this Disease
  • HSP
  • Familial spastic paraparesis
  • FSP
Related Diseases
  • Hereditary spastic paraplegia - autosomal dominant inheritance
  • Hereditary spastic paraplegia - autosomal recessive inheritance
  • Hereditary spastic paraplegia – maternal inheritance
  • Hereditary spastic paraplegia - X-linked inheritance
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.