Hereditary spastic paraplegia
Other Names for this Disease
- Familial spastic paraparesis
- Hereditary spastic paraplegia - autosomal dominant inheritance
- Hereditary spastic paraplegia - autosomal recessive inheritance
- Hereditary spastic paraplegia – maternal inheritance
- Hereditary spastic paraplegia - X-linked inheritance
upper motor neurons. Upper motor neurons in the brain and spinal cord deliver signals to the lower motor neurons which in turn, carry messages to the muscles. In hereditary spastic paraplegia, upper motor neurons slowly degenerate so the muscles do not receive the correct messages causing progressive spasticity (increased muscle tone/stiffness) and weakness of the legs leading to difficulty walking. As degeneration continues, symptoms worsen.Hereditary spastic paraplegia is a group of hereditary, degenerative, neurological disorders that primarily affect the
Last updated: 1/31/2013
- Fink JK. A Comparison of Hereditary Spastic Paraparesis (HSP) and Primary Lateral Sclerosis (PLS). Spastic Paraplegia Foundation, Inc.. November 22, 2013; http://sp-foundation.org/understanding-hsp-pls/overview-summary-chart/. Accessed 10/22/2014.
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