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Diseases

Genetic and Rare Diseases Information Center (GARD)

Hidradenitis suppurativa

*

* Not a rare disease

Other Names for this Disease
  • Acne inversa
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Cause

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What causes hidradenitis suppurativa?

The underlying cause of hidradenitis suppurativa (HS ) is not known in most cases. Researchers suspect that there may be several potential underlying causes of genetic, endocrine, microbiological, and environmental origin.[1][2]

A family history of HS is reported in approximately 1/3 patients. Researcher suspect that HS is inherited or passed down in an autosomal dominant manner. This means that if an individual inherits HS, they have a 50% chance to pass it to the next generation. These risks may be lower, as there are likely other influences that impact one's likelihood of developing HS. Researchers are currently trying to identify which genes may be implicated in HS. Some cases have been found to result from mutations in the NCSTN, PSEN1, or PSENEN gene. More studies are needed to determine whether other genes might be involved.[2][3]

Last updated: 7/6/2016

References
  1. Jovanovic M. Hidradenitis Suppurativa. Medscape Reference. January 5, 2015; http://emedicine.medscape.com/article/1073117-overview#showall. Accessed 3/6/2015.
  2. Ingram JR. The Genetics of Hidradenitis Suppurativa. Dermatol Clin. January 2016; 34(1):23-28. http://www.ncbi.nlm.nih.gov/pubmed/26617354.
  3. Hidradenitis suppurativa. Genetics Home Reference. December 2013; http://ghr.nlm.nih.gov/condition/hidradenitis-suppurativa. Accessed 3/6/2015.


Other Names for this Disease
  • Acne inversa
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.