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Diseases

Genetic and Rare Diseases Information Center (GARD)

Hidradenitis suppurativa

*

* Not a rare disease

Other Names for this Disease
  • Acne inversa
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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What are the signs and symptoms of Hidradenitis suppurativa?

Hidradenitis suppurativa is characterized by:[1]

  • Small pitted areas of skin containing blackheads;
  • Red, tender bumps or lesions that enlarge, break open and drain pus that may have an unpleasant odor; 
  • Painful hard lumps that develop under the skin and may enlarge and/or persist for years; and 
  • Leaking bumps or sores that heal very slowly and can lead to scarring and tunnels under the skin (called sinus tracts).

Hidradenitis suppurativa commonly occurs in areas near hair follicles where there are many oil and sweat glands; places like the armpit, groin and anal area. It can also occur in areas where skin rubs together, including the inner thighs, under the breasts, and between the buttocks.[1][2]

This condition most often presents after puberty and can persist for years, worsening over time. Three stages of disease have been described which progress from single or localized abscesses accompanied by itching or discomfort, to recurrent abscesses that occur in multiple locations, to widespread severe disease that can restrict movement, obstruct lymph drainage and lead to social isolation.[2][3]

Last updated: 10/6/2015

The Human Phenotype Ontology provides the following list of signs and symptoms for Hidradenitis suppurativa. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Recurrent cutaneous abscess formation 90%
Abnormality of temperature regulation 50%
Acne 50%
Atypical scarring of skin 50%
Pruritus 50%
Arthritis 7.5%
Hyperhidrosis 7.5%
Intestinal fistula 7.5%
Lymphedema 7.5%
Microcytic anemia 7.5%
Neoplasm of the skin 7.5%
Weight loss 7.5%
Acne inversa -
Autosomal dominant inheritance -

Last updated: 2/1/2016

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Hidradenitis suppurativa: Symptoms. Mayo Clinic. April 9, 2013; http://www.mayoclinic.org/diseases-conditions/hidradenitis-suppurativa/basics/symptoms/con-20027334. Accessed 10/6/2015.
  2. Kidradenitis suppurativa. The Hidradenitis Suppurativa Trust. November 10, 2012; http://www.hstrust.org/info.html. Accessed 10/6/2015.
  3. Lee R. Hidradenitis Suppurativa. National Organization of Rare Disorders Web site. 2012; http://rarediseases.org/rare-diseases/hidradenitis-suppurativa/. Accessed 3/6/2015.


Other Names for this Disease
  • Acne inversa
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.