Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Huntington disease


Other Names for this Disease
  • Huntington's chorea
  • Huntington's disease
  • HD
  • Huntington chorea
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Inheritance

Newline Maker

How is Huntington disease inherited?

Huntington disease (HD) is inherited in an autosomal dominant manner.[1] This means that having a change (mutation) in only one of the 2 copies of the HTT gene is enough to cause the condition. When a person with HD has children, each child has a 50% (1 in 2) chance to inherit the mutated gene and develop the condition.

Most people with HD have an affected parent. The family history can sometimes appear negative for various reasons even though a parent carries, or carried, a mutation in the HTT gene. In rare cases, HD is caused by a new (de novo) mutation in the HTT gene, in which case the disease occurs for the first time in the affected person and is not inherited from a parent.[1]

As HD is passed through generations, the size of the mutation in the HTT gene (called a trinucleotide repeat) often increases. A longer repeat in the HTT gene may cause earlier onset of symptoms. This phenomenon is called anticipation.[2]
Last updated: 10/21/2015

References
  1. Simon C Warby, Rona K Graham, and Michael R Hayden. Huntington Disease. GeneReviews. December 11, 2014; http://www.ncbi.nlm.nih.gov/books/NBK1305/.
  2. Huntington disease. Genetics Home Reference. June, 2013; http://ghr.nlm.nih.gov/condition/huntington-disease.


Other Names for this Disease
  • Huntington's chorea
  • Huntington's disease
  • HD
  • Huntington chorea
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.