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Diseases

Genetic and Rare Diseases Information Center (GARD)

Isaacs' syndrome


Other Names for this Disease
  • Neuromyotonia
  • Isaac's-Merten's syndrome
  • Continuous muscle fiber activity syndrome
  • Quantal squander syndrome
  • Acquired neuromyotonia
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Overview

Isaacs' syndrome is a rare neuromuscular disorder that is characterized by progressive muscle stiffness; continuously contracting or twitching muscles (myokymia); and diminished reflexes. Signs and symptoms generally develop between ages 15 and 60, with most people experiencing symptoms before age 40. Although the exact underlying cause is unknown, there appear to be hereditary and acquired (non-inherited) forms of the condition. Treatment is based on the sign and symptoms present in each person.[1][2][3]
Last updated: 9/17/2015

References

  1. NINDS Isaac's Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). September 2015; http://www.ninds.nih.gov/disorders/isaacs_syndrome/isaacs_syndrome.htm.
  2. Suying Song. Myokymia. Medscape Reference. November 2014; http://emedicine.medscape.com/article/1141267-overview.
  3. Ahmed A, Simmons Z. Isaacs syndrome: A review. Muscle Nerve. July 2015; 52(1):5-12.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Merck Manual for health care professionals provides information on Isaacs' syndrome.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Isaacs' syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Neuromyotonia
  • Isaac's-Merten's syndrome
  • Continuous muscle fiber activity syndrome
  • Quantal squander syndrome
  • Acquired neuromyotonia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.