Other Names for this Disease
- Acquired neuromyotonia
- Continuous muscle fiber activity syndrome
- Isaac syndrome
- Isaac's-Merten's syndrome
- Isaac-Mertens syndrome
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The treatment of Isaacs' syndrome is based on the signs and symptoms present in each person. For example, anticonvulsant medications such as phenytoin and carbamazepine may be prescribed to relieve stiffness, muscle spasms, and pain. Plasma exchange may provide short-term relief for people with some forms of acquired Isaacs' syndrome. Plasma exchange is a method by which whole blood is removed from the body and processed so that the red and white blood cells are separated from the plasma (liquid portion of the blood). The blood cells are then returned to the patient without the plasma, which the body quickly replaces. If there is no response or poor response to plasma exchange, some studies suggest that intravenous infusions of immunoglobulins (IvIg therapy) may be beneficial.
Last updated: 9/17/2015
- NINDS Isaac's Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). September 2015; http://www.ninds.nih.gov/disorders/isaacs_syndrome/isaacs_syndrome.htm.
- Ahmed A, Simmons Z. Isaacs syndrome: A review. Muscle Nerve. July 2015; 52(1):5-12.
- Finding Treatment Information - A video developed by GARD Information Specialists that explains how you can find information about treatment for a rare disease.
- ClinicalTrials.gov lists trials that are studying or have studied Isaacs' syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.