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Diseases

Genetic and Rare Diseases Information Center (GARD)

Kartagener syndrome


Other Names for this Disease
  • Dextrocardia bronchiectasis and sinusitis
  • PCD
  • Primary ciliary dyskinesia
  • Siewert syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Symptoms

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What are the signs and symptoms of Kartagener syndrome?

Kartagener syndrome is characterized by primary ciliary dyskinesia and situs inversus totalis. In people affected by situs inversus totalis, the internal organs including the heart, liver, spleen and intestine are on the opposite side of the body. Although the internal organs are abnormally placed, this condition typically does not cause any health problems.[1][2]

The signs and symptoms of primary ciliary dyskinesia vary, but may include:[1][2][3]
Last updated: 2/1/2015

The Human Phenotype Ontology provides the following list of signs and symptoms for Kartagener syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms.

Signs and Symptoms Approximate number of patients (when available)
Recurrent respiratory infections 90%
Abnormal respiratory motile cilium morphology -
Abnormality of the cornea -
Absent frontal sinuses -
Anosmia -
Asplenia -
Autosomal recessive inheritance -
Bronchiectasis -
Chronic otitis media -
Chronic rhinitis -
Chronic sinusitis -
Ciliary dyskinesia -
Communicating hydrocephalus -
Conductive hearing impairment -
Headache -
Heterogeneous -
Immotile cilia -
Male infertility -
Nasal polyposis -
Pneumonia -
Sinusitis -
Situs inversus totalis -

Last updated: 9/1/2015

The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature.

The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined.

Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common.


References
  1. Primary Ciliary Dyskinesia. NORD. June 2012; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/526/viewAbstract.
  2. Maimoona A Zariwala, PhD, FACMG, Michael R Knowles, MD, and Margaret W Leigh, MD. Primary Ciliary Dyskinesia. GeneReviews. February 2013; http://www.ncbi.nlm.nih.gov/books/NBK1122/.
  3. John P Bent lll, MD. Kartagener Syndrome. Medscape Reference. February 2014; http://emedicine.medscape.com/article/299299-overview.


Other Names for this Disease
  • Dextrocardia bronchiectasis and sinusitis
  • PCD
  • Primary ciliary dyskinesia
  • Siewert syndrome
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.