Your browser does not support javascript:   Search for gard hereSearch for news-and-events here.

Diseases

Genetic and Rare Diseases Information Center (GARD)

Kennedy disease


Other Names for this Disease
  • Spinal and bulbar muscular atrophy
  • X-linked spinal and bulbar muscular atrophy
  • Bulbospinal muscular atrophy
  • X-linked bulbospinal amyotrophy
  • Spinobulbar muscular atrophy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.

Inheritance

Newline Maker

How is Kennedy disease inherited?

Kennedy disease is inherited in an X-linked recessive manner. A condition is X-linked if the mutated responsible gene is located on the X chromosome (one of the two sex chromosomes). Males have one X chromosome and one Y chromosome, while females have two X chromosomes. In males, one mutated copy of a disease-causing gene on the X chromosome is enough to cause the condition. In females, a mutation usually must be present in both copies of the gene (one on each X chromosome) to cause the condition.[1]

A characteristic of X-linked inheritance is that affected males cannot pass X-linked traits to their sons, because they only pass their Y chromosome to their sons.[1] However, all daughters of an affected male will be carriers of the condition. A female carrier of an X-linked recessive condition has a 50% chance to pass the mutated gene on to each daughter (i.e. there is a 50% chance each daughter will also be a carrier) and a 50% chance to pass the mutated gene on to each son (i.e. there is a 50% chance that each son will be affected).
Last updated: 9/21/2015

References
  1. Spinal and bulbar muscular atrophy. Genetics Home Reference. May 2006; http://ghr.nlm.nih.gov/condition/spinal-and-bulbar-muscular-atrophy. Accessed 9/28/2012.


Other Names for this Disease
  • Spinal and bulbar muscular atrophy
  • X-linked spinal and bulbar muscular atrophy
  • Bulbospinal muscular atrophy
  • X-linked bulbospinal amyotrophy
  • Spinobulbar muscular atrophy
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.