Other Names for this Disease
- Cutaneous sebaceous neoplasms and keratoacanthomas multiple with gastrointestinal and other carcinomas
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Lynch syndrome and is characterized by sebaceous (oil gland) skin tumors in association with internal cancers. The most common internal site involved is the gastrointestinal tract (with almost half of affected people having colorectal cancer), followed by the genitourinary tract. Skin lesions may develop before or after the diagnosis of the internal cancer. MTS is caused by changes (mutations) in the MLH1 or MSH2 genes and is inherited in an autosomal dominant manner. A mutation in either of these genes gives a person an increased lifetime risk of developing the skin changes and types of cancer associated with the condition.Muir-Torre syndrome (MTS) is a form of
Last updated: 6/11/2015
- Torre-Muir syndrome. DermNet NZ. January 24, 2015; http://www.dermnetnz.org/systemic/torre-muir.html.
- Victor A. McKusick. MUIR-TORRE SYNDROME; MRTES. OMIM. October 10, 2014; http://www.omim.org/entry/158320.
- Muir-Torre Syndrome. Cancer.Net (American Society of Clinical Oncology). September, 2014; http://www.cancer.net/cancer-types/muir-torre-syndrome.
- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
- The American Society of Clinical Oncology provides information on Muir-Torre syndrome. Click on the link to view this information.
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Muir-Torre syndrome. Click on the link to view a sample search on this topic.