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Diseases

Genetic and Rare Diseases Information Center (GARD)

Lambert Eaton myasthenic syndrome


Other Names for this Disease
  • LEMS
  • Eaton Lambert syndrome
  • Lambert Eaton syndrome
  • Myasthenic syndrome of Lambert-Eaton
  • Myasthenic-Myopathic syndrome of Lambert-Eaton
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Treatment

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How might Lambert-Eaton myasthenic syndrome be treated?

Medications and therapies used to treat Lambert-Eaton myasthenic syndrome may include anticholinesterase agents (e.g., Pyridostigmine), guanidine hydrochloride, plasmapheresis (where blood plasma is removed and replaced with fluid, protein, or donated plasma) or IV immunoglobulins, steroids (e.g., prednisone), azathioprine or cyclosporine, and/or 3,4-diaminopyridine.[1]

3,4-diaminopyridine is available in Europe and may be available in the U.S. on a compassionate use basis. While there has been some evidence that either 3,4-diaminopyridine or IV immunoglobulin can improve muscle strength and nerve to muscle cell communication, the degree of benefit (i.e., how much symptoms are improved) still needs to be determined.[1]
Last updated: 10/9/2009

References
  1. Stevens RD. Neuromuscular disorders and anesthesia. Curr Opin Anaesthesiol. 2001 Dec;


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Clinical Trials & Research for this Disease

  • ClinicalTrials.gov lists trials that are studying or have studied Lambert Eaton myasthenic syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.
Other Names for this Disease
  • LEMS
  • Eaton Lambert syndrome
  • Lambert Eaton syndrome
  • Myasthenic syndrome of Lambert-Eaton
  • Myasthenic-Myopathic syndrome of Lambert-Eaton
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.