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Diseases

Genetic and Rare Diseases Information Center (GARD)

Lambert Eaton myasthenic syndrome


Other Names for this Disease
  • LEMS
  • Eaton Lambert syndrome
  • Lambert Eaton syndrome
  • Myasthenic syndrome of Lambert-Eaton
  • Myasthenic-Myopathic syndrome of Lambert-Eaton
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Overview

Lambert Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction. The neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles.[1] This syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. It may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. Symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth.[1] Treatment of a underlying disorder or cancer is the first priority of treatment.
Last updated: 4/22/2011

References

  1. NINDS Lambert-Eaton Myasthenic Syndrome Information Page. Institute of Neurological Disorders and Stroke (NINDS). 2007; http://www.ninds.nih.gov/disorders/lambert_eaton/lambert_eaton.htm. Accessed 10/28/2009.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Lambert Eaton myasthenic syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • LEMS
  • Eaton Lambert syndrome
  • Lambert Eaton syndrome
  • Myasthenic syndrome of Lambert-Eaton
  • Myasthenic-Myopathic syndrome of Lambert-Eaton
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.