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Diseases

Genetic and Rare Diseases Information Center (GARD)

Laron syndrome


Other Names for this Disease
  • Growth hormone insensitivity syndrome
  • Pituitary dwarfism II
  • Growth hormone receptor deficiency
  • Primary growth hormone resistance
  • Primary growth hormone insensitivity
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Tests & Diagnosis

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How is Laron syndrome diagnosed?

A diagnosis of Laron syndrome is often suspected based on the presence of characteristic signs and symptoms. Additional testing can then be ordered to confirm the diagnosis and rule out other conditions that cause similar features. This generally includes blood tests to measure the levels of certain hormones that are often abnormal in people with Laron syndrome. For example, affected people may have elevated levels of growth hormone and reduced levels of insulin-like growth factor I. Genetic testing for changes (mutations) in the GHR gene can also be used to confirm a diagnosis in some cases.[1][2]
Last updated: 9/30/2015

References
  1. Laron Z. Growth hormone insensitivity (Laron syndrome). Rev Endocr Metab Disord. December 2002; 3(4):347-355.
  2. Alan D Rogol, MD, PhD. Growth hormone insensitivity syndromes. UpToDate. August 2015; Accessed 9/29/2015.


Testing

  • The Genetic Testing Registry (GTR) provides information about the genetic tests for this condition. The intended audience for the GTR is health care providers and researchers. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.
Other Names for this Disease
  • Growth hormone insensitivity syndrome
  • Pituitary dwarfism II
  • Growth hormone receptor deficiency
  • Primary growth hormone resistance
  • Primary growth hormone insensitivity
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.